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Formula Fights Fleas and TicksZodiac Spot On Flea and Tick Control is a medication that consists of a special formula known as the IGR (Insect Growth Regulator) that helps break the lifecycle of fleas by killing eggs and larvae. Zodiac Spot On Flea and Tick Control comes with a special applicator that is designed to keep the flea and tick applications separate. It"s customized for small, medium and large-sized dogs.